Fast and binary assay for predicting radiosensitivity based on the nucleoshuttling of ATM protein: development, validation and performances

Our recent approach that predicts adverse tissue reactions after radiotherapy has stressed the role of the nucleoshuttling of the ATM protein. However, although very reliable it requires cellular amplification which protracts process up to some weeks. Here, we proposed a predictive assay based on the quantification of the pATM proteins via ELISA technique that renders much faster our previous approach. Such fast assay elicits the highest statistical performance among the fastest predictive approaches available.

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