Frontal infraslow activity marks the motor spasms of anti-LGI1 encephalitis

The clinical and electrographic features of seizures in anti-LGI1 encephalitis are distinct from those seen in other autoimmune encephalitides or non-encephalitic epilepsies. The recognition of unusual lateralized motor spasms, which have come to be known as faciobrachial dystonic seizures (FBDS) (Irani et al., 2011a), has greatly facilitated early clinical diagnosis of the condition. Electrographically, a pattern of unusually frequent subclinical temporal lobe seizures in the absence of interictal spikes has been identified as an independent diagnostic marker (Andrade et al., 2011a,b; Steriade et al., 2016).

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