Reply to “The insular cortex and QTc interval in HIV+ and HIV- individuals: Is there an effect of sympathetic nervous system activity?”

The correspondence by Nagai et al. (2017a) raised several points regarding our interpretation of the lateralized effects for QTc interval length on resting functional connectivity (rsFC) of the ventromedial prefrontal cortex (VMPFC) (McIntosh et al., 2017). The authors first contend that if some form of sympathetic inhibition accounts for prolongation of the QT interval in a dog model then a similar mechanism, i.e., parasympathetic arousal, would be expected to correspond with longer QTc interval lengths in our sample of HIV+ and HIV-negative men.

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