The Role of Genetic Counseling in Familial and Sporadic Cancer: Considerations, Challenges, and Collaboration

With the advent of increasingly affordable genetic sequencing technology, commercial laboratories have begun to offer an array of multigene panels for hereditary cancer assessment. Further, precision medicine efforts aimed at identifying mutational drug targets through tumor (somatic) sequencing are also uncovering inherited mutations. Germline alterations themselves are increasingly being considered as therapeutic targets. Genetic counseling for inherited cancer risk must rapidly evolve to keep pace, and internists are often on the front lines for identifying patients who could benefit from genetic consultation.

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