Liver volume as a predictor of functional improvement post DAA treatment

Background New direct antiviral agents (DAA) for HCV treatment result in sustained viral response (SVR) in most patients. However, predicting the point of no-return is still an unmet need for those with advanced liver disease. Aim to assess if baseline liver volume is a predictor of post-SVR liver function. Methods Cirrhotic patients assessed for liver transplantation (LT) and consecutively treated with DAA between September 2014 and 2015 who achieved an SVR were included. Pretreatment liver (LV) and spleen (SV) volumes adjusted by Body Surface Area (BSA) were calculated from CT/MR images. Liver function was assessed by Child-Turcotte-Pugh (CTP) and MELD scores and a multivariate mixed regression model was used to identify baseline factors associated with improvement of liver function overtime. Results We included 42 patients with a median age of 58.6 years (Q1-Q3: 52.7 - 68.8); MELD, 14 (11-17); CTP, 9 (8-10); LV, 1400.9 mL (1183.2-1601.4); SV, 782.9 mL (490.6-1118.8). MELD scores at baseline and at last control were 14 (11-17) and 10 (8-12), respectively (p

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