Critical appraisal of the risk of secondary cancer induction from breast radiotherapy with volumetric modulated arc therapy relative to 3D conformal therapy

Excess absolute risk (EAR) was estimated for breast cancer patients receiving volumetric modulated arc therapy (VMAT) delivery with two planning approaches (VMAT_tang and VMAT_full), or 3D conformal radiotherapy with field-in-field setting. Dose prescription was 40.05 Gy in 15 fractions. Almost no difference was computed for EAR to contralateral organs between VMAT_tang and field-in-field, with the first presenting significant normal tissue complication probability reduction for ipsilateral organs. VMAT can be safely used for breast cancer treatment.

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