Antifungal susceptibility of emerging dimorphic pathogens in the family Ajellomycetaceae [PublishAheadOfPrint]

The in vitro susceptibility of 24 molecularly identified dimorphic fungi belonging to Adiaspiromyces, Blastomyces and Emergomyces within the family Ajellomycetaceae was tested against 8 standard antifungals using CLSI M38-A2. Amphotericin B and posaconazole had the lowest geometric mean MICs (< 0.05μg/ml) followed by itraconazole (< 0.07μg/ml), voriconazole (< 0.15μg/ml) and isavuconazole (< 0.42μg/ml) while fluconazole was not active. Micafungin demonstrated good in vitro antifungal activity against Emergomyces (GM-MEC 0.1μg/ml) and Blastomyces (GM-MEC < 0.017μg/ml).

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