Analyses of a Mutant Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells

Hayatsu et al. report that an IPEX-associated Foxp3 mutation has expanded DNA recognition specificity and impairs tissue Treg cell fitness by repressing Batf. Their findings identify BATF as a critical regulator of tissue Treg cells and suggest that polymorphisms that impact Foxp3-DNA interactions may contribute to susceptibility to autoimmune disease.

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