Symptom cluster in men with castrate resistant prostate cancer

Men with metastatic castrate resistant prostate cancer (CRPC) experience significant physical and mental health morbidity along with impaired quality of life (QoL).1 Pain related to skeletal metastases is the predominant physical symptom, but patients also suffer fatigue and drowsiness. On average, each prostate cancer patient has a median of four clinically relevant symptoms (defined as ≥4/10 on the Edmonton Symptom Assessment Scale (ESAS)).2 Treatment related symptoms may also occur such as loss of libido, hot flashes, depression, osteoporosis, fatigue, weight gain, erectile dysfunction and cognitive impairment with hormone suppression.

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