A phase I/II dose escalation study of the use of intensity modulated radiotherapy (IMRT) to treat the prostate and pelvic nodes in patients with prostate cancer

Elective pelvic lymph node (PLN) radiotherapy and hypofractionation for advanced localised prostate cancer remains controversial. We report a single-centre sequential cohort study using IMRT to deliver conventionally-fractionated 50Gy, 55Gy, and 60Gy to the PLN and 70-74Gy (2Gy/fraction) to the prostate. Additionally we studied modest hypofractionation delivering 60Gy (3Gy/fraction) to the prostate with 47Gy to the PLN over 4-5 weeks. Our findings highlight the safety of dose-escalation and hypofractionation in PLN-IMRT.

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