Vancomycin-Induced Nephrotoxicity in Adolescents Receiving Extended Infusion: Case Series.

Because of concerns of red man syndrome, our institution increased standard vancomycin infusion duration to 90 minutes for 1000-mg doses and 120 minutes for 2000-mg doses. However, in children and adolescents, the dosing interval remained every 6 to 8 hours. The purpose of this pilot study was to identify the incidence of supratherapeutic vancomycin serum concentrations (VSCs) and nephrotoxicity with extended-infusion vancomycin (>=90 minutes). Of the 7 adolescents who received extended-infusion vancomycin, 1 (14.2%) experienced supratherapeutic VSC and nephrotoxicity. Extended-infusion vancomycin for red man syndrome should include assessment of the dosing interval and frequent VSC monitoring if a 6-hour interval is indicated. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.

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