Biologic Agents in the Treatment of Childhood-Onset Rheumatic Disease

Over the last 20 years, newly developed biologic therapeutic agents have revolutionized treatment and outcomes in rheumatology and several other areas of medicine. In the best of circumstances, biologic agents can maximize both effectiveness and safety through highly specific inhibition of targeted molecules and cell types. Several effective biologics have been developed and approved by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of adult rheumatic conditions, such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and systemic lupus erythematosus (SLE).

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