We could predict good responders to vagus nerve stimulation: a surrogate marker by slow cortical potential shift

Vagus nerve stimulation (VNS) is a palliative treatment option for patients with intractable epilepsy who are not good candidates for surgical resection (Connor et al., 2012). VNS uses an electrical stimulator, like those in cardiac pacemakers, which is implanted in the subclavicular area and delivers trains of electrical pulses to the left vagus nerve via bipolar stimulating electrodes (Terry et al., 1990). The stimulation of the vagus nerve is intermittent, and the usual stimulation condition is set to a signal on-time (VNS ON) of 30 s followed by an off-time (VNS OFF) of 3–5 min (Heck et al., 2002) repeatedly.

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