Treatment of Klebsiella pneumoniae Carbapenemase-Producing Klebsiella pneumoniae Bacteremia With Meropenem, Colistin, and Ceftazidime-Avibactam: A Case Report.

Ceftazidime-avibactam is a novel combination antimicrobial agent consisting of a broad-spectrum cephalosporin, ceftazidime, and a non-[beta]-lactam [beta]-lactamase inhibitor, avibactam. This agent has demonstrated activity against resistant gram-negative bacteria, including Klebsiella pneumoniae carbapenemase-producing organisms; however, it is US Food and Drug Administration approved for use in urinary tract and intra-abdominal infections only. We present a case of successful treatment of K. pneumoniae carbapenemase-producing K. pneumoniae bacteremia with a combination of meropenem and colistin followed by ceftazidime-avibactam and colistin. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.

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