Reply

We appreciate the opportunity to respond to Meyer et al regarding our recent publication from the Trial of Late Surfactant (TOLSURF), describing the effects of late surfactant with inhaled nitric oxide on the respiratory status of high-risk extremely preterm infants, as determined at 1 year corrected age. We agree with the points raised by the writers, and described by Hines et al,1 regarding variability in the literature related to the diagnosis of bronchopulmonary dysplasia (BPD).1 The clinical definitions of BPD are muddied by clinical practices, while the physiological definitions depend on the cut-off used for adequate oxygen saturation, and require only a relatively brief time period to maintain that saturation level.

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