Comparing Newer GFR Estimating Equations Using Creatinine and Cystatin C to the CKD-EPI Equations in Adults

GFR estimation using creatinine, cystatin C, or both is now widely used in clinical practice in adults. Use of a single equation for each filtration marker (or combination) for eGFR reporting would facilitate patient care. KDIGO guidelines recommend using the CKD-EPI equations, but other equations are recommended if they are more accurate.1 The CKD-EPI equations were developed and validated in studies of diverse populations of adults in North America and Europe, including black and white individuals, those with and without CKD, and those with and without diabetes, and have been extensively validated by other research groups in these subgroups and in the elderly.

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