Abstract The fast hybrid operator splitting (HOS) and stable uniformization (UNI) methods have been proposed to save computation cost and enhance stability for Markov chain model in cardiac cell simulations. Moreover, Chen-Chen-Luo’s quadratic adaptive algorithm (CCL) combined with HOS or UNI was used to improve the tradeoff between speedup and stability, but without considering accuracy. To compromise among stability, acceleration, and accuracy, we propose a generalized Trotter...
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Publication date: Available online 15 July 2020Source: CortexAuthor(s): Jennifer N. Gutsell, Jeremy C. Simon, Yanyi Jiang
Wed Jul 15, 2020 17:01
Publication date: Available online 15 July 2020Source: CortexAuthor(s): Elliot Freeman
Wed Jul 15, 2020 17:01
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. With the ameliorated resectability prowess of endoscopic techniques, a myriad of diseases previously treated by major ablative surgeries are now endoscopically curable. Endoscopic submucosal tunnel dissection (ESTD) is a relatively new technique that has diversified endoscopic application. Although ESTD has frequently been used for the resection of esophageal neoplastic lesions, the clinical evidence...
Wed Jul 15, 2020 13:02
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Capillary leak syndrome (CLS) is characterized by plasma extravasation into the interstitium with resultant hypotension, anasarca, hemoconcentration, and hypoalbuminemia in the absence of albuminuria. Initially reported in Clarkson’s disease (systemic capillary leak syndrome), CLS has been observed in multiple disease settings, the most common being sepsis. In oncology, CLS has been reported more...
Wed Jul 15, 2020 12:54
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Thyroid nodules are palpable on up to 7% of asymptomatic patients. Cancer is present in 8% to 16% of those patients with previously identified thyroid nodules. Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer, accounting for approximately 85% of thyroid cancers. Although most appear as solid nodules on ultrasound imaging, a subset of 2.5% to 6% has cystic components. The...
Wed Jul 15, 2020 12:54
Abstract Aims Childhood DCM is a leading cause of heart failure requiring cardiac transplantation and approximately 5% of cases result in sudden death. Knowledge of the underlying genetic cause can aid prognostication and clinical management and enables accurate recurrence risk counselling for the family. Here we used genomic sequencing to identify the causative genetic variant(s) in families with children affected by severe DCM. Methods and Results In an international collaborative...
Wed Jul 15, 2020 11:51
Tue Jul 14, 2020 21:13
Abstract Congenital anomalies of the kidney and urinary tract (CAKUT) is the leading cause of end‐stage kidney disease in children. Until now, more than 50 monogenic causes for CAKUT have been described, all of which only explain 10‐20% of all patients with CAKUT, suggesting the presence of additional genes that cause CAKUT when mutated. Herein, we report two siblings of a consanguineous family with CAKUT, both of which rapidly progressed to chronic kidney disease (CKD) in early childhood....
Tue Jul 14, 2020 20:25
Abstract FGFR1 is an idiopathic hypogonadotropic hypogonadism (IHH)‐associated gene, mutated in approximately 10% of the patients with this condition. Through targeted gene sequencing of 153 males with IHH and 100 healthy controls, we identified ten mutations in FGFR1 from IHH patients with a frequency of 5.9% in the Chinese population of central China. These included nine missense mutations(NM_023110.2, p.Gly687Arg, p.Ala608Asp, p.Gly348Glu, p.Asn296Ser, p.Gly226Asp, p.Arg209Cys, p.Gly97Arg,...
Tue Jul 14, 2020 20:25
Abstract Jews are estimated to be at increased risk of pancreatic cancer compared to non-Jews, but their observed 50–80% excess risk is not explained by known non-genetic or genetic risk factors. We conducted a GWAS in a case–control sample of American Jews, largely Ashkenazi, including 406 pancreatic cancer patients and 2332 controls, identified in the dbGaP, PanScan I/II, PanC4 and GERA data sets. We then examined resulting SNPs with P < 10–7 in an expanded sample set, of...
Wed Jul 15, 2020 03:00
Introduction: A wide range of pulse widths (PWs) has been used in globus pallidus internus (GPi) deep brain stimulation (DBS) for dystonia. However, no specific PW has demonstrated clinical superiority, and the paradigm may differ among DBS centers. Objective: To investigate how different paradigms of PWs in GPi DBS for dystonia affect implantable pulse generator (IPG) longevities and energy consumption. Methods: Thirty-nine patients with dystonia treated with bilateral GPi DBS at 2 Swedish DBS centers...
Wed Jul 15, 2020 08:40
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and spread globally, causing a pandemic of respiratory illness designated coronavirus disease 2019 (Covid-19). The urgent need for vaccines prompted an international response, with more than 120 candidate…
Tue Jul 14, 2020 03:00
Related Articles User-dependent Usability and Feasibility of a Swallowing Training mHealth App for Older Adults: A Preliminary Mixed Methods Study. JMIR Mhealth Uhealth. 2020 Jun 14;: Authors: Kim H, Lee SH, Cho NB, You H, Choi T, Kim J Abstract BACKGROUND: Swallowing difficulties (i.e., dysphagia) are common among older adults, with a 13%-54% prevalence. Adequate interventions to improve the swallowing function of older adults would reduce...
Wed Jul 15, 2020 16:00
Abstract Introduction In anti-osteoporosis drug trials, vitamin D and calcium (Ca) are common supplements; however, the optimal dose of each is unclear. Using data from the randomized, double-blind, placebo-controlled DIRECT trial, we assessed whether baseline serum 25-hydroxy vitamin D (25[OH]D) level influences the efficacy of denosumab co-administered with vitamin D and Ca. ...
Wed Jul 15, 2020 03:00
New Findings What is the central question of this study? This study sought to evaluate whether thyroid hormone treatment given after myocardial infarction could preserve the left ventricular function, treadmill exercise performance, and improve parameters of oxidative stress in the right ventricle and lungs of Wistar rats. What is the main finding and its importance? The main contribution of this study is the finding that thyroid hormone treatment improved the performance of the...
Wed Jul 15, 2020 13:35
Related Articles CT Angiography of Agenesis of the Left Internal Carotid Artery. Radiology. 2020 Jul 14;:201289 Authors: Shitara S Abstract Online supplemental material is available for this article. PMID: 32662763 [PubMed - as supplied by publisher]
Wed Jul 15, 2020 15:52
Related Articles MRI Assessment of Chylous and Nonchylous Effusions: Use of Multipoint Dixon Fat Quantification. Radiology. 2020 Jul 14;:200089 Authors: Kuetting D, Luetkens J, Fimmers R, Sprinkart AM, Attenberger U, Pieper CC Abstract Background Diagnosis of chylous effusions normally requires invasive paracentesis. Purpose To assess whether MRI with multipoint Dixon fat quantification allows for noninvasive differentiation of chylous...
Wed Jul 15, 2020 15:52
Related Articles Predicting PET Cerebrovascular Reserve with Deep Learning by Using Baseline MRI: A Pilot Investigation of a Drug-Free Brain Stress Test. Radiology. 2020 Jul 14;:192793 Authors: Chen DYT, Ishii Y, Fan AP, Guo J, Zhao MY, Steinberg GK, Zaharchuk G Abstract Background Cerebrovascular reserve (CVR) may be measured by using an acetazolamide test to clinically evaluate patients with cerebrovascular disease. However, acetazolamide...
Wed Jul 15, 2020 15:52
Related Articles Dual-Energy CT for Suspected Radiographically Negative Wrist Fractures: A Prospective Diagnostic Test Accuracy Study. Radiology. 2020 Jul 14;:192701 Authors: Müller FC, Gosvig KK, Børgesen H, Gade JS, Brejnebøl M, Rodell A, Nèmery M, Boesen M Abstract Background Patients with wrist trauma and negative findings on radiographs often undergo additional MRI examinations to assess for radiographically occult fractures. Dual-energy...
Wed Jul 15, 2020 15:52
Related Articles Estimating Recurrence after Upfront Surgery in Patients with Resectable Pancreatic Ductal Adenocarcinoma by Using Pancreatic CT: Development and Validation of a Risk Score. Radiology. 2020 Jul 14;:200281 Authors: Kim DW, Lee SS, Kim SO, Kim JH, Kim HJ, Byun JH, Yoo C, Kim KP, Song KB, Kim SC Abstract Background No preoperative model is available for predicting postsurgical prognosis of patients with resectable pancreatic...
Wed Jul 15, 2020 15:52
Related Articles Thoracic Bone Mineral Density Derived from Cardiac CT Is Associated with Greater Fracture Rate. Radiology. 2020 Jul 14;:192706 Authors: Therkildsen J, Nissen L, Jørgensen HS, Thygesen J, Ivarsen P, Frost L, Isaksen C, Langdahl BL, Hauge EM, Boettcher M, Winther S Abstract Background Osteoporosis is a prevalent, under-diagnosed, and treatable disease associated with increased fracture risk. Bone mineral density (BMD) derived...
Wed Jul 15, 2020 15:52
Publication date: July–August 2020Source: Revista Española de Medicina Nuclear e Imagen Molecular, Volume 39, Issue 4Author(s): Irene Casáns-Tormo, Amelia Jiménez-Heffernan
Wed Jul 15, 2020 15:49
Publication date: July–August 2020Source: Revista Española de Medicina Nuclear e Imagen Molecular, Volume 39, Issue 4Author(s):
Wed Jul 15, 2020 15:49
Publication date: Available online 15 July 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Stephan Christian Möhlhenrich, Jana Heeg, Stefan Raith, Kristian Kniha, Frank Hölzle, Michael Wolf, Ulrike Fritz, Ali Modabber
Wed Jul 15, 2020 15:35
Wed Jul 15, 2020 12:21
Abstract Onychomycosis is a common chronic fungal infection of the nails caused by dermatophytes, yeasts and non‐dermatophyte filamentous fungi. A relatively high incidence of resistance and treatment failure of onychomycosis to traditional systemic antifungal agents such as terbinafine and itraconazole has been reported. Voriconazole is a novel broad spectrum systemic antifungal that has shown high efficacy against various types of dermatophytes including Trichophyton and Microsporum species in...
Wed Jul 15, 2020 12:11
Abstract Background Behçet's Disease (BD) is an auto‐inflammatory disease characterized by systemic vasculitis. Monocyte to HDL‐cholesterol ratio (MHR), monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR) are used as inflammatory markers in many disorders. Colchicine decreases inflammation by suppressing the secretion of pro‐inflammatory cytokines. This study aims to examine the effects of colchicine treatment on MHR, MLR, and NLR levels of the patients with BD. Material...
Wed Jul 15, 2020 12:04
Publication date: 1 December 2020Source: Talanta, Volume 220Author(s): Nan Wang, Minggang Xie, Mengke Wang, Zhengxuan Li, Xingguang Su
Wed Jul 15, 2020 15:23
Publication date: 1 December 2020Source: Talanta, Volume 220Author(s): Zhibo Tong, Mingqi Xu, Qian Li, Chang Liu, Yunliang Wang, Jingquan Sha
Wed Jul 15, 2020 15:23
Publication date: 1 December 2020Source: Talanta, Volume 220Author(s): Hang Zhang, Weiping Ding, Shibo Li, Shengnan Ya, Fenfen Li, Bensheng Qiu
Wed Jul 15, 2020 15:23
Publication date: 1 December 2020Source: Talanta, Volume 220Author(s): Rui Lv, Rui Shi, Enhui Wu, Chongqing Ma, Ruochen Guo, Jing Li, Fuzhong Ouyang, Qianqian Fang, Lihua Hu, Chang Sun, Yang Liu, Zhenhui Kang, Jian Liu
Wed Jul 15, 2020 15:23
Publication date: 1 November 2020Source: Talanta, Volume 219Author(s): Paula Berman, Liron Sulimani, Anat Gelfand, Keren Amsalem, Gil M. Lewitus, David Meiri
Wed Jul 15, 2020 15:23
Publication date: 1 November 2020Source: Talanta, Volume 219Author(s): Jia-Wei Zhang, Ling Tan, Jin-Bin Yuan, Ri-Fa Qiao, Chong-Zhi Wang, Feng-Qing Yang, Lian-Di Zhou, Qi-Hui Zhang, Zhi-Ning Xia, Chun-Su Yuan
Wed Jul 15, 2020 15:23
Publication date: 1 November 2020Source: Talanta, Volume 219Author(s): Chen Cao, Yan Feng, Hao Li, Yang Yang, Xuerui Song, Yingzhe Wang, Guolin Zhang, Wei Dou, Weisheng Liu
Wed Jul 15, 2020 15:23
This study uncovers the wide intraspecific diversity of tooth form in the large‐spotted catshark Scyliorhinus stellaris using micro‐computed tomography and 3D geometric morphometrics. We characterize the emergence of sexual dimorphism along ontogenetic stages using sex‐specific ontogenetic trajectories. We discuss the physical and chemical parameters acting on tooth morphogenesis that may generate the described developmental plasticity in elasmobranchs. Abstract Teeth in sharks are shed and...
Wed Jul 15, 2020 14:35
The histology of basaloid squamous cell carcinoma (BSCC) can resemble that of adenoid cystic carcinoma (AdCC). Herein, we report two cases of BSCC with adenoid cystic‐like features (BSCC‐AdC). We collected cases of AdCC and BSCC of the head and neck region, extracted two cases with unusual histology, and reexamined them histologically and immunohistochemically. Case 1 involved an 81‐year‐old Japanese male, who had an elastic‐hard mass on the left side of his tongue, and a biopsy examination suggested...
Wed Jul 15, 2020 13:51
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