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Although a large part of the symptomology of coronavirus disease 2019 (COVID-19) has been attributed to its effects in the lungs, the virus has also been shown to cause extensive cardiovascular complications in a small subset of patients. In this case report, we describe a 29-year-old nonobese hospital food service associate who presented with diffuse abdominal and chest pain; he was found to be positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with significantly elevated...
Wed Jul 15, 2020 20:50
Background. The investigation of volatile oils used in traditional medicine is vital to enhance the quality of healthcare. This study is aimed at screening the antioxidant and antimicrobial properties of Micromeria fruticosa serpyllifolia volatile oils from three different regions in Palestine (north, middle, and south). Methods. Volatile oils of three samples of M. fruticosa serpyllifolia were extracted using the microwave-ultrasonic apparatus. The antioxidant activity of the volatile oils was assessed...
Wed Jul 15, 2020 17:50
Objective. This study is designed to clarify that miR-1258 targets E2F1 to regulate the proliferation and cell cycle of breast cancer (BC) cells and consequently suppress the progression of BC. Methods. Bioinformatics analysis was used to analyze the differentially expressed genes in BC. The expression of miR-1258 and E2F1 mRNA in BC cell lines and immortalized breast epithelial cell lines were detected by qRT-PCR. The proliferation and growth activity of BC cells were detected by MTT and colony...
Wed Jul 15, 2020 17:35
Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation Microenvironment
Lung injury and inflammation are complex pathological processes. The influence and crosstalk between various cells form a characteristic microenvironment. Extracellular vesicles from different cell sources in the microenvironment carry multiple cargo molecules, which affect the pathological process through different pathways. Here, we mainly discussed the mechanism of crosstalk between alveolar epithelial cells and different immune cells through extracellular vesicles in lung inflammation and reviewed...
Wed Jul 15, 2020 17:05
The main aim was to analyse the associations between several physical fitness variables and bone parameters in a sample of elderly people. 129 participants (94 females and 35 males, ) from the EXERNET cohort of Zaragoza (Spain) were included in the study. Physical fitness was assessed using the Senior Fitness Test Battery. Peripheral quantitative computed tomography (pQCT) at the tibia and dual-energy X-ray absorptiometry (DXA) at the hip and lumbar spine were used to assess bone and muscle parameters....
Wed Jul 15, 2020 16:50
Gelsemium elegans (Gardn. & Champ.) Benth. is a plant belonging to the genus Gelsemium (family Gelsemiaceae), and its main components are alkaloids. It is a Chinese traditional medicinal plant and notoriously known as a highly toxic medicine. However, a method has not yet been found for the simultaneous detection of 11 Gelsemium alkaloids in rat plasma, and the toxicokinetics of 11 Gelsemium alkaloids after intravenous administration has not been reported. In this work, we have developed a sensitive...
Wed Jul 15, 2020 16:50
Purposes. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. Recent researches have demonstrated that m6A methylation regulators play a key role in various cancers, such as gastric cancer and colon adenocarcinoma. Several m6A methylation regulators are reported to predict the prognosis of HCC. Therefore, there is a need to further identify the predictive value of m6A methylation regulators in HCC. Methods. We utilized The Cancer Genome Atlas (TCGA) database to...
Wed Jul 15, 2020 16:35
Cardiovascular and cerebrovascular diseases caused by atherosclerosis have a high disability rate and reduce the quality of life of the population. Therefore, understanding the mechanism of atherosclerosis and its control may interfere with the progression of atherosclerosis and thus control the occurrence of diseases closely related to atherosclerosis. TSP-1 is a factor that has been found to have an antiangiogenic effect, and CD47, as the receptor of TSP-1, can participate in the regulation of...
Wed Jul 15, 2020 16:20
Missing observations are always a challenging problem that we have to deal with in diseases that require follow-up. In hospital records for vesicoureteral reflux (VUR) and recurrent urinary tract infection (rUTI), the number of complete cases is very low on demographic and clinical characteristics, laboratory findings, and imaging data. On the other hand, deep learning (DL) approaches can be used for highly missing observation scenarios with its own missing ratio algorithm. In this study, the effects...
Wed Jul 15, 2020 12:50
As a subclass of noncoding RNAs, circular RNAs (circRNAs) have been demonstrated to play a critical role in regulating gene expression in eukaryotes. Recent studies have revealed the pivotal functions of circRNAs in cancer progression. Nevertheless, how circRNAs participate in osteosarcoma (OS) development and progression are not well understood. In the present study, we identified a circRNA circFAT1(e2) with an upregulated expression level in OS tissues. By functional experiments, we found that...
Wed Jul 15, 2020 12:50
The global incidence of sepsis is increasing, and mortality remains high. The mortality is even higher in resource-poor countries where facilities and equipment are limited. The Surviving Sepsis Campaign (SSC) recommends an updated hour-1 bundle based on the evidence from the International Guidelines for Management of Sepsis and Septic Shock 2018. To reduce mortality from sepsis, compliance with the “bundle” is essential. Data from developing countries like Sri Lanka on the management of sepsis according...
Wed Jul 15, 2020 12:35
This study investigated the effects of therapeutic singing as an intervention for improving the vocal functions of the elderly. Data collection for this study took place at five senior community centers in Seoul, South Korea, from August 2018 to March 2019. A total of 54 elderly with healthy voices were assigned to a therapeutic singing group, a general singing group, or a control group, using convenience sampling. The therapeutic singing intervention involved using the Alexander technique, performing...
Wed Jul 15, 2020 03:00
The purpose of this study was to determine the feasibility of altering speech breathing patterns and dysphonia severity through training increased levels of lung volume use during speech. It was hypothesized that respiratory-based training would increase lung volume levels during speech as well as improve acoustic voice measures, and that the addition of laryngeal-based treatment would further improve voice acoustics by treatment completion.
Wed Jul 15, 2020 03:00
Stem Cells and Development, Ahead of Print.
Mon Jul 13, 2020 10:00
Stem Cells and Development, Ahead of Print.
Mon Jul 13, 2020 10:00
Stem Cells and Development, Ahead of Print.
Mon Jul 13, 2020 10:00
On November 25, 2019, Chilean feminist collective, Las Tesis, gathered in Santiago’s Plaza de Armas. Against a backdrop of anti-Piñera graffiti painted on government buildings, museums, and Catholic church properties, some 50 members of the collective wearing black blindfolds began to chant a rhythm now heard around the world. The patriarchy is a judge that judges us for being born and our punishment is the violence you don’t see… The lyrics continue on to connect patriarchal state structures...
00:15
Businesses want and need anthropologists. It’s time we claimed our skills and told industry leaders what our training and expertise can do for them. Anthropological concepts, methods, and knowledge are currently being used or sought after in the business world, but not always employed by people with our unique training and global mindset. Ethnography, culture, and holism are hot topics, applied by management consultants, behavioral economists, and industrial and organizational psychologists to...
00:00
The treatment of head and neck cancer (HNC) is often radical and the patient’s journey challenging, especially for individuals who are struggling with pre-existing mental health problems and who lack social support. Patients frequently suffer from high levels of emotional distress at some point before, during, or after treatment, and their risk of suicide is markedly elevated. This structured review aimed to identify the extent of the problem, appropriate interventions, and areas for future research.
Wed Jul 15, 2020 03:00
The two-week rule (2WR) referral system was designed to fast-track patients with suspected malignancies to secondary care services to facilitate prompt investigation and management, the ultimate goals being early detection and improved survival. Patients with symptoms of head and neck cancer primarily present to the general practitioner (GP) who has an important role in the identification of high-risk patients for prompt management. This paper reports urgent 2WR referrals from primary care to highlight...
Wed Jul 15, 2020 03:00
Mucoceles are common in the minor salivary and sublingual glands. Sclerotherapy is a possible treatment strategy for mucoceles. The purpose of this study was to evaluate the clinical outcomes of sclerotherapy with promethazine hydrochloride injection in treating mucoceles. Thirty-seven patients were enrolled. Sclerotherapy was performed with promethazine hydrochloride injection (25mg/ml) through the mucosa. Patients were followed up at 1, 3, and 6 months after the last sclerotherapy. Clinical data...
Wed Jul 15, 2020 03:00
In mandibular surgery, three-dimensionally printed patient-specific cutting guides are used to translate the preoperative virtually planned resection planes to the operating room. This study was performed to determine whether cutting guides are positioned according to the virtual plan and to compare the intraoperative position of the cutting guide with the resection performed. Nine patients were included. The exact positions of the resection planes were planned virtually and a patient-specific cutting...
Wed Jul 15, 2020 03:00
The primary aim of this observational study was to describe the incidence of postoperative pulmonary complications (PPCs) in 60 consecutive, surgically treated head and neck cancer patients requiring free flap reconstruction and tracheostomy, using both a prospective and a retrospective outcome measure. Secondary aims were to identify risk factors for PPC development, explore the effects of PPC on outcomes, and describe the provision of postoperative physiotherapy in this population. Postoperative...
Wed Jul 15, 2020 03:00
The aim of this study was to compare the costs and benefits of surgery-first (SF) and orthodontics-first (OF) approaches in patients with skeletal class III malocclusion. This retrospective study recruited 54 patients who received combined orthognathic–orthodontic treatment via SF or OF approach. Data collected included orthodontic time, operating time, hospital stay, and detailed expenditures. Effectiveness was defined as quality of life, assessed by Orthognathic Quality of Life Questionnaire (OQLQ-22)...
Wed Jul 15, 2020 03:00
Background Immunodeficiency is a risk factor for recalcitrant chronic rhinosinusitis (CRS). Currently, there is no consensus on effective treatment modalities for immunodeficient CRS patients. This review aims to evaluate the existing evidence on the treatment outcomes and its limitations in patients with CRS and immunodeficiency. Methods MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from inception to April 2019 for studies reporting measurable...
Wed Jul 15, 2020 21:52
Background Acute invasive fungal sinusitis (AIFS) is a potentially life‐threatening diagnosis in immunocompromised patients. Identifying patients who could benefit from evaluation and intervention can be challenging for referring providers and otolaryngologists alike. We aimed to develop and validate an accessible diagnostic tool to estimate the probability of AIFS. Methods Retrospective chart review from 1999 to 2017 identified all patients evaluated for possible AIFS at a tertiary care center....
Wed Jul 15, 2020 21:35
Soft Robotics, Ahead of Print.
Mon Jul 13, 2020 10:00
Soft Robotics, Ahead of Print.
Mon Jul 13, 2020 10:00
Soft Robotics, Ahead of Print.
Mon Jul 13, 2020 10:00
Soft Robotics, Ahead of Print.
Mon Jul 13, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Mon Jul 13, 2020 10:00
Dating back to the last universal common ancestor (LUCA), the P-loop NTPases and Rossmanns now comprise the most ubiquitous and diverse enzyme lineages. Intriguing similarities in their overall architecture and phosphate binding motifs suggest common ancestry; however, due to a lack of global sequence identity, these families are considered independent emergences. To address this longstanding dichotomy, we systematically searched for 'bridge proteins' with structure and sequence elements shared by...
Wed Jul 15, 2020 03:00
Atlantic herring is widespread in North Atlantic and adjacent waters and is one of the most abundant vertebrates on earth. This species is well suited to explore genetic adaptation due to minute genetic differentiation at selectively neutral loci. Here we report hundreds of loci underlying ecological adaptation to different geographic areas and spawning conditions. Four of these represent megabase inversions confirmed by long read sequencing. The genetic architecture underlying ecological adaptation...
Wed Jul 15, 2020 03:00
To describe a living organism it is often said that the whole is greater than the sum of its parts. In genetics, we may also think that the effect of multiple mutations on an organism is greater than their additive individual effect, a phenomenon called epistasis or multiplicity. Despite the last decade's discovery that many disease- and fitness-related traits are polygenic, or controlled by many genetic variants, it is still debated whether the effects of individual genes combine additively or not....
Wed Jul 15, 2020 03:00
Hybridization is differentially manifested across the genome, with selection and migration effectively balancing the expression of introgressed genes. These issues can now be effectively quantified through the unprecedented resolution of contemporary sequencing technologies, such that researchers can identify genetic elements involved in cross-species exchange. Furthermore, genomic patterns can now be associated with ecologically relevant phenotypes, given availability of annotated reference genomes....
Wed Jul 15, 2020 03:00
The recently published complete mitochondrial genome of the endangered Knysna seahorse, Hippocampus capensis Boulenger, 1900, was based on a specimen obtained from a Traditional Chinese Medicine market. As H. capensis is endemic to temperate South Africa and exceptionally rare, illegal trade to supply Asian markets would constitute a considerable extinction risk. I investigated the phylogenetic placement of the Chinese specimen using mitochondrial DNA control region and cytochrome b sequences from...
Wed Jul 15, 2020 03:00
White Guinea yam (Dioscorea rotundata) is an important staple tuber crop of West Africa. However, its origin remains unclear. In this study, we re-sequenced 336 accessions of white Guinea yam and compared them with the sequences of the wild Dioscorea species using an improved reference genome sequence of D. rotundata. Our results suggest a hybrid origin of white Guinea yam from crosses between the rainforest wild species D. praehensilis and the savannah-adapted D. abyssinica. We identified a higher...
Wed Jul 15, 2020 03:00
The marine ciliate Mesodinium rubrum is famous for its ability to acquire and exploit chloroplasts and other cell organelles from some cryptophyte algal species. We sequenced genomes and transcriptomes of free-swimming Teleaulax amphioxeia, as well as well-fed and starved M. rubrum in order to understand cellular processes upon sequestration under different prey and light conditions. From its prey, the ciliate acquires the ability to photosynthesize as well as the potential to metabolize several...
Wed Jul 15, 2020 03:00
The Tricolored Blackbird (Agelaius tricolor) is a colonial songbird, found almost exclusively in California, whose total population size has sharply declined over the past century. It is currently under review to be listed as Endangered under both the California and U.S. Endangered Species Acts. Here we assess the genetic diversity of a breeding population in California's Central Valley, comparing our findings with previously sampled conspecific and congeneric populations. First, we genotyped 50...
Wed Jul 15, 2020 03:00
The North American tiger salamander species complex, including its flagship species the axolotl, has long been a source of biological fascination. The complex exhibits a wide range of variation in developmental life history strategies, including populations and individuals that undergo metamorphosis and those able to forego metamorphosis and retain a larval, aquatic lifestyle (i.e., paedomorphosis). Such disparate life history strategies are assumed to cause populations to become reproductively isolated,...
Wed Jul 15, 2020 03:00
Animals display remarkable diversity in rest and activity patterns that are regulated by endogenous foraging strategies, social behaviors, and predator avoidance. Alteration in the circadian timing of activity or the duration of rest-wake cycles provide a central mechanism for animals to exploit novel niches. The diversity of the 3000 cichlid species throughout the world provides a unique opportunity to examine variation in locomotor activity and rest. Lake Malawi alone is home to over 500 species...
Tue Jul 14, 2020 03:00
Background: An organism tree of a group of extant-organisms can be considered as a conceptual tree to capture a simplified narrative of the evolutionary course among the organisms. Due to the difficulties of whole-genome sequencing for many organisms, the most common approach has been to construct a gene tree by selecting a group of genes common among the organisms, align each gene family and estimate evolutionary distances. Despite broad acceptance of the gene trees as the surrogates for the organism...
Tue Jul 14, 2020 03:00
Gene tree discordance in large genomic datasets can be caused by evolutionary processes such as incomplete lineage sorting and hybridization, as well as model violation, and errors in data processing, orthology inference, and gene tree estimation. Species tree methods that identify and accommodate all sources of conflict are not available, but a combination of multiple approaches can help tease apart alternative sources of conflict. Here, using a phylotranscriptomic analysis in combination with reference...
Tue Jul 14, 2020 03:00
Incomplete lineage sorting (ILS), the interaction between coalescence and speciation, is a process which generates incongruences between gene trees and species trees, as do gene duplication (D), transfer (T) and loss (L). These processes are usually modelled independently, but in reality, ILS can affect gene copy number polymorphism, i.e., interfere with DTL. This has been previously recognised, but not treated in a satisfactory way, mainly because DTL events are naturally modelled forward-in-time,...
Tue Jul 14, 2020 03:00
A major goal in biology is to understand how evolution shapes variation in individual life histories. Genome-wide association studies have been successful in uncovering genome regions linked with traits underlying life history variation in a range of species. However, lack of functional studies of the discovered genotype-phenotype associations severely restrains our understanding how alternative life history traits evolved and are mediated at the molecular level. Here, we report a cis-regulatory...
Tue Jul 14, 2020 03:00
Conn’s syndrome is a curable condition if identified properly. It is characterized by autonomous secretion of aldosterone from the adrenal gland cortex. Its morbidity is related to the increased risk of cardio...
Wed Jul 15, 2020 03:00
One of the important pathogeneses of eustachian tube dysfunction (ETD) is nasal inflammatory disease. The prevalence of allergic rhinitis (AR) in adults ranges from 10 to 30% worldwide. However, research on th...
Wed Jul 15, 2020 03:00
Although the diagnosis and management of chronic spontaneous urticaria (CSU) is well documented in the literature, some aspects of the disease remain unclear. We aimed to further describe the natural history, ...
Wed Jul 15, 2020 03:00
Wed Jul 15, 2020 20:48
Wed Jul 15, 2020 20:28
Wed Jul 15, 2020 20:10
We present a freely available workflow built for rapid exploration and accurate analysis of cellular bodies in specific cell compartments in fluorescence microscopy images. This user-friendly workflow is designed on the open-source software Icy and also uses ImageJ functionalities. The pipeline is affordable without knowledge in image analysis.
Wed Jul 15, 2020 21:26
Publication date: Available online 15 July 2020Source: Human PathologyAuthor(s): John M. Gross, Stephen M. Broski, Benjamin M. Howe, Andrew L. Folpe
Wed Jul 15, 2020 21:19
The Hearing Network Alliance (HNA), an American Association of Payers, Administrators, and Networks (AAPAN) alliance organization, launched a streamlined credentialing process to reduce the cost and effort required for hearing care providers to manage credentialing with the hearing health care networks in which they participate. Initially, five hearing health care networks have agreed to utilize the new process for primary source verification."We have heard many times from providers that the credentialing...
Wed Jul 15, 2020 14:13
Abstract Background In the subcategorization of atypical glandular cells (AGCs), origin of cells should be mentioned to estimate lesion sites for diagnosis. However, cases without subcategorization are often encountered due to limited reproducibility. We evaluated whether the subcategorization of AGC based on the Bethesda terminology can estimate lesion sites. Methods We retrospectively investigated cases whose cervical smears were interpreted as AGC and underwent pathological assessment...
Wed Jul 15, 2020 19:24
Wed Jul 15, 2020 18:23
Abstract Hypothalamic orexin/hypocretin neurons integrate multiple sensory cues and project brain‐wide to orchestrate multiple innate behaviours. Their loss impairs many context‐appropriate actions, but the motivational characteristics of orexin cell activity remain unclear. We and others previously approached this question by artificial orexin stimulation, which could induce either rewarding (positive valence) and aversive (negative valence) brain activity. It is unknown to what extent such approaches...
Wed Jul 15, 2020 18:19
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