Antibiotics, Vol. 9, Pages 412: Antibacterial Drug Development: A New Approach Is Needed for the Field to Survive and Thrive Antibiotics doi: 10.3390/antibiotics9070412 Authors: M. Courtney Safir Sujata M. Bhavnani Christine M. Slover Paul G. Ambrose Christopher M. Rubino It is often said that the marketplace for new antibiotics is broken. This notion is supported by the observation that many recently-approved antibiotics to treat drug-resistant bacteria have failed commercially...
Wed Jul 15, 2020 03:00
Antibiotics, Vol. 9, Pages 411: Antibacterial Activity of Bacteriocinogenic Commensal Escherichia coli against Zoonotic Strains Resistant and Sensitive to Antibiotics Antibiotics doi: 10.3390/antibiotics9070411 Authors: Justyna Mazurek-Popczyk Justyna Pisarska Ewa Bok Katarzyna Baldy-Chudzik Antibiotic resistance concerns various areas with high consumption of antibiotics, including husbandry. Resistant strains are transmitted to humans from livestock and agricultural products...
Wed Jul 15, 2020 03:00
Antibiotics, Vol. 9, Pages 410: Profile of Enterobacteria Resistant to Beta-Lactams Antibiotics doi: 10.3390/antibiotics9070410 Authors: Andressa Liberal Santos Adailton Pereira dos Santos Célia Regina Malveste Ito Pedro Henrique Pereira de Queiroz Juliana Afonso de Almeida Marcos Antonio Batista de Carvalho Júnior Camila Zanatta de Oliveira Melissa Ameloti G. Avelino Isabela Jubé Wastowski Giselle Pinheiro Lima Aires Gomes Adenícia Custódia Silva e Souza Lara...
Wed Jul 15, 2020 03:00
Antioxidants, Vol. 9, Pages 621: Hydrogen Sulfide: From a Toxic Molecule to a Key Molecule of Cell Life Antioxidants doi: 10.3390/antiox9070621 Authors: Aroca Gotor Bassham Romero Hydrogen sulfide (H2S) has always been considered toxic, but a huge number of articles published more recently showed the beneficial biochemical properties of its endogenous production throughout all regna. In this review, the participation of H2S in many physiological and pathological processes...
Wed Jul 15, 2020 03:00
Antioxidants, Vol. 9, Pages 622: Anti-Inflammatory Effects of Ribes diacanthum Pall Mediated via Regulation of Nrf2/HO-1 and NF-κB Signaling Pathways in LPS-Stimulated RAW 264.7 Macrophages and a TPA-Induced Dermatitis Animal Model Antioxidants doi: 10.3390/antiox9070622 Authors: Na Yeon Kim Sun Hee Cheong Kun Jong Lee Dai-Eun Sok Mee Ree Kim Ribes diacanthum Pall (RDP) is a Mongolian traditional medicine used to treat renal inflammation. In the present study, we initially...
Wed Jul 15, 2020 03:00
Antioxidants, Vol. 9, Pages 620: Enteromorpha prolifera Extract Improves Memory in Scopolamine-Treated Mice via Downregulating Amyloid-β Expression and Upregulating BDNF/TrkB Pathway Antioxidants doi: 10.3390/antiox9070620 Authors: Seung Yeon Baek Fu Yi Li Da Hee Kim Su Jin Kim Mee Ree Kim Enteromorpha prolifera, a green alga, has long been used in food diets as well as traditional remedies in East Asia. Our preliminary study demonstrated that an ethyl acetate extract of...
Wed Jul 15, 2020 03:00
Antioxidants, Vol. 9, Pages 619: Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview Antioxidants doi: 10.3390/antiox9070619 Authors: Ansary Forbes-Hernández Gil Cianciosi Zhang Elexpuru-Zabaleta Simal-Gandara Giampieri Battino Garlic is a polyphenolic and organosulfur enriched nutraceutical spice consumed since ancient times. Garlic and its secondary metabolites have shown excellent health-promoting and disease-preventing...
Wed Jul 15, 2020 03:00
Antioxidants, Vol. 9, Pages 618: Antioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Status Antioxidants doi: 10.3390/antiox9070618 Authors: Azahara I. Rupérez María D. Mesa Augusto Anguita-Ruiz Esther M. González-Gil Rocío Vázquez-Cobela Luis A. Moreno Ángel Gil Mercedes Gil-Campos Rosaura Leis Gloria Bueno Concepción M. Aguilera Oxidative stress could help explain the relationship between childhood obesity and...
Wed Jul 15, 2020 03:00
Antioxidants, Vol. 9, Pages 617: Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) and Mitochondrial Dynamics/Mitophagy in Neurological Diseases Antioxidants doi: 10.3390/antiox9070617 Authors: Tae-Cheon Kang Mitochondria play an essential role in bioenergetics and respiratory functions for cell viability through numerous biochemical processes. To maintain mitochondria quality control and homeostasis, mitochondrial morphologies change rapidly in response to external insults and changes...
Wed Jul 15, 2020 03:00
Atmosphere, Vol. 11, Pages 749: Monitoring Excess Exposure to Air Pollution for Professional Drivers in London Using Low-Cost Sensors Atmosphere doi: 10.3390/atmos11070749 Authors: Louise Bøge Frederickson Shanon Lim Hugo Savill Russell Szymon Kwiatkowski James Bonomaully Johan Albrecht Schmidt Ole Hertel Ian Mudway Benjamin Barratt Matthew Stanley Johnson In this pilot study, low-cost air pollution sensor nodes were fitted in waste removal trucks, hospital...
Wed Jul 15, 2020 03:00
Atmosphere, Vol. 11, Pages 748: High-Resolution Temperature Variability Reconstructed from Black Pine Tree Ring Densities in Southern Spain Atmosphere doi: 10.3390/atmos11070748 Authors: Esper Hartl Tejedor de Luis Günther Büntgen The presence of an ancient, high-elevation pine forest in the Natural Park of Sierras de Cazorla in southern Spain, including some trees reaching >700 years, stimulated efforts to develop high-resolution temperature reconstructions...
Wed Jul 15, 2020 03:00
Atmosphere, Vol. 11, Pages 750: Poor Air Quality and Its Association with Mortality in Ho Chi Minh City: Case Study Atmosphere doi: 10.3390/atmos11070750 Authors: Vu Ha Nguyen Nguyen Nguyen Nguyen Tran Ho Along with its rapid urban development, Ho Chi Minh City (HCMC) in recent years has suffered a high concentration of air pollutants, especially fine particulate matters or PM2.5. A comprehensive study is required to evaluate the air quality conditions and...
Wed Jul 15, 2020 03:00
Biology, Vol. 9, Pages 166: Plasma CAF22 Levels as a Useful Predictor of Muscle Health in Patients with Chronic Obstructive Pulmonary Disease Biology doi: 10.3390/biology9070166 Authors: Rizwan Qaisar Asima Karim Tahir Muhammad Skeletal muscle dysfunction and reduced physical capacity are characteristic features of chronic obstructive pulmonary disease (COPD). However, the search for a reliable biomarker to assess muscle health in CODP remains elusive. We analyzed the course of...
Wed Jul 15, 2020 03:00
Biology, Vol. 9, Pages 165: Potential Involvement of lncRNAs in the Modulation of the Transcriptome Response to Nodavirus Challenge in European Sea Bass (Dicentrarchus labrax L.) Biology doi: 10.3390/biology9070165 Authors: Patricia Pereiro Raquel Lama Rebeca Moreira Valentina Valenzuela-Muñoz Cristian Gallardo-Escárate Beatriz Novoa Antonio Figueras Long noncoding RNAs (lncRNAs) are being increasingly recognised as key modulators of various biological mechanisms, including...
Wed Jul 15, 2020 03:00
Biology, Vol. 9, Pages 164: Vegetation- and Environmental Changes on Non-Reclaimed Spoil Heaps in Southern Poland Biology doi: 10.3390/biology9070164 Authors: Oimahmad Rahmonov Robert Krzysztofik Dorota Środek Justyna Smolarek-Lach The study focused on the changes in vegetation and soils on an undeveloped area of coal mine spoil heaps. The process of vegetation changes was evaluated on the basis of historical cartographic materials and fieldwork. Changes of vegetation in nearly...
Wed Jul 15, 2020 03:00
Biomedicines, Vol. 8, Pages 215: Ectopic Expression of Hematopoietic SHIP1 in Human Colorectal Cancer Biomedicines doi: 10.3390/biomedicines8070215 Authors: Matthias Schaks Kristina Allgoewer Nina Nelson Patrick Ehm Asmus Heumann Florian Ewald Udo Schumacher Ronald Simon Guido Sauter Manfred Jücker Colorectal cancer (CRC) is a heterogeneous disease that results from the accumulation of mutations in colonic mucosa cells. A subclass of CRC is characterized by...
Wed Jul 15, 2020 03:00
Biomedicines, Vol. 8, Pages 214: Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45lowCD271+ Multipotential Stromal Cells (BM-MSCs): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation Biomedicines doi: 10.3390/biomedicines8070214 Authors: Payal Ganguly Agata Burska Charlotte Davis Jehan J. El-Jawhari Peter V. Giannoudis Elena Jones Skeletal aging is associated with reduced proliferative potential of bone marrow (BM) multipotential...
Wed Jul 15, 2020 03:00
Biomimetics, Vol. 5, Pages 34: Biomimetic Aspects of Restorative Dentistry Biomaterials Biomimetics doi: 10.3390/biomimetics5030034 Authors: Muhammad Zafar Faiza Amin Muhmmad Fareed Hani Ghabbani Samiya Riaz Zohaib Khurshid Naresh Kumar Biomimetic has emerged as a multi-disciplinary science in several biomedical subjects in recent decades, including biomaterials and dentistry. In restorative dentistry, biomimetic approaches have been applied for a range of applications,...
Wed Jul 15, 2020 03:00
Biomolecules, Vol. 10, Pages 1056: Using Coarse-Grained Simulations to Characterize the Mechanisms of Protein–Protein Association Biomolecules doi: 10.3390/biom10071056 Authors: Kalyani Dhusia Zhaoqian Su Yinghao Wu The formation of functionally versatile protein complexes underlies almost every biological process. The estimation of how fast these complexes can be formed has broad implications for unravelling the mechanism of biomolecular recognition. This kinetic property is traditionally...
Wed Jul 15, 2020 03:00
Biomolecules, Vol. 10, Pages 1055: Vitamin D Prevents Pancreatic Cancer-Induced Apoptosis Signaling of Inflammatory Cells Biomolecules doi: 10.3390/biom10071055 Authors: Stefania Moz Nicole Contran Monica Facco Valentina Trimarco Mario Plebani Daniela Basso Combined approaches based on immunotherapy and drugs supporting immune effector cell function might increase treatment options for pancreatic ductal adenocarcinoma (PDAC), vitamin D being a suitable drug candidate....
Wed Jul 15, 2020 03:00
Biomolecules, Vol. 10, Pages 1053: Erratum: Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles. Biomolecules 2020, 10, 416 Biomolecules doi: 10.3390/biom10071053 Authors: Alex B. Addinsall Leonard G. Forgan Natasha L. McRae Rhys W. Kelly Penny L. McDonald Bryony McNeill Daniel R. McCulloch Nicole Stupka The authors wish to make a change to this published paper [...]
Wed Jul 15, 2020 03:00
Biomolecules, Vol. 10, Pages 1052: Coumarin Ameliorates Impaired Bone Turnover by Inhibiting the Formation of Advanced Glycation End Products in Diabetic Osteoblasts and Osteoclasts Biomolecules doi: 10.3390/biom10071052 Authors: Eun-Jung Lee Min-Kyung Kang Yun-Ho Kim Dong Yeon Kim Hyeongjoo Oh Soo-Il Kim Su Yeon Oh Woojin Na Young-Hee Kang Accumulating evidence demonstrates that the risk of osteoporotic fractures increases in patients with diabetes mellitus....
Wed Jul 15, 2020 03:00
Biomolecules, Vol. 10, Pages 1054: Biochemical Composition of Cumin Seeds, and Biorefining Study Biomolecules doi: 10.3390/biom10071054 Authors: Othmane Merah Bouchra Sayed-Ahmad Thierry Talou Zeinab Saad Muriel Cerny Sarah Grivot Philippe Evon Akram Hijazi A new biorefinery approach has been developed in the present study, and applied on cumin (Cuminum cyminum) seeds as a potential source of phytochemicals of interest. Cumin is a popular spice used widely for its...
Wed Jul 15, 2020 03:00
Biomolecules, Vol. 10, Pages 1050: Deamidated Human Triosephosphate Isomerase is a Promising Druggable Target Biomolecules doi: 10.3390/biom10071050 Authors: Sergio Enríquez-Flores Luis Antonio Flores-López Itzhel García-Torres Ignacio de la Mora-de la Mora Nallely Cabrera Pedro Gutiérrez-Castrellón Yoalli Martínez-Pérez Gabriel López-Velázquez Therapeutic strategies for the treatment of any severe disease are based on the discovery and validation of druggable targets....
Wed Jul 15, 2020 03:00
Biomolecules, Vol. 10, Pages 1049: Untargeted Profiling of Bile Acids and Lysophospholipids Identifies the Lipid Signature Associated with Glycemic Outcome in an Obese Non-Diabetic Clinical Cohort Biomolecules doi: 10.3390/biom10071049 Authors: Nicolas Christinat Armand Valsesia Mojgan Masoodi The development of high throughput assays for assessing lipid metabolism in metabolic disorders, especially in diabetes research, nonalcoholic fatty liver disease (NAFLD), and nonalcoholic...
Wed Jul 15, 2020 03:00
Biomolecules, Vol. 10, Pages 1051: Glutamate-Gated NMDA Receptors: Insights into the Function and Signaling in the Kidney Biomolecules doi: 10.3390/biom10071051 Authors: José M. Valdivielso Àuria Eritja Maite Caus Milica Bozic N-Methyl-d-aspartate receptor (NMDAR) is a glutamate-gated ionotropic receptor that intervenes in most of the excitatory synaptic transmission within the central nervous system (CNS). Aside from being broadly distributed in the CNS and having indispensable...
Wed Jul 15, 2020 03:00
Biomolecules, Vol. 10, Pages 1048: The Gintonin-Enriched Fraction of Ginseng Regulates Lipid Metabolism and Browning via the cAMP-Protein Kinase A Signaling Pathway in Mice White Adipocytes Biomolecules doi: 10.3390/biom10071048 Authors: Kippeum Lee Heegu Jin Sungwoo Chei Hyun-Ji Oh Sun-Hye Choi Seung-Yeol Nah Boo-Yong Lee Obesity is a major health concern and is becoming an increasingly serious societal problem worldwide. The browning of white adipocytes has received...
Wed Jul 15, 2020 03:00
Biomolecules, Vol. 10, Pages 1047: Subcritical Methanol Extraction of the Stone of Japanese Apricot Prunus mume Sieb. et Zucc. Biomolecules doi: 10.3390/biom10071047 Authors: Tomoaki Kawabata Yoshie Tanaka Asako Horinishi Megumi Mori Asao Hosoda Nami Yamamoto Takahiko Mitani The pits of Japanese apricot, Prunus mume Sieb. et Zucc., which are composed of stones, husks, kernels, and seeds, are unused by-products of the processing industry in Japan. The processing of Japanese...
Wed Jul 15, 2020 03:00
Brain Sciences, Vol. 10, Pages 453: A Multiple N-Glucosylated Peptide Epitope Efficiently Detecting Antibodies in Multiple Sclerosis Brain Sciences doi: 10.3390/brainsci10070453 Authors: Francesca Nuti Feliciana Real Fernandez Giuseppina Sabatino Elisa Peroni Barbara Mulinacci Ilaria Paolini Margherita Di Pisa Caterina Tiberi Francesco Lolli Martina Petruzzo Roberta Lanzillo Vincenzo Brescia Morra Paolo Rovero Anna Maria Papini Diagnostics of Multiple...
Wed Jul 15, 2020 03:00
Brain Sciences, Vol. 10, Pages 454: Non-Invasive Brain Stimulation: Augmenting the Training and Performance Potential in Esports Players Brain Sciences doi: 10.3390/brainsci10070454 Authors: Wei Zhuang Keyi Yin Yahua Zi Yu Liu During the last two decades, esports, a highly competitive sporting activity, has gained increasing popularity. Both performance and competition in esports require players to have fine motor skills and physical and cognitive abilities in controlling and...
Wed Jul 15, 2020 03:00
Brain Sciences, Vol. 10, Pages 452: Perfusion and Metabolic Neuromonitoring during Ventricular Taps in Infants with Post-Hemorrhagic Ventricular Dilatation Brain Sciences doi: 10.3390/brainsci10070452 Authors: Ajay Rajaram Lawrence C. M. Yip Daniel Milej Marianne Suwalski Matthew Kewin Marcus Lo Jeffrey J. L. Carson Victor Han Soume Bhattacharya Mamadou Diop Sandrine de Ribaupierre Keith St. Lawrence Post-hemorrhagic ventricular dilatation (PHVD) is characterized...
Wed Jul 15, 2020 03:00
Cancers, Vol. 12, Pages 1916: Effect of Flow-Induced Shear Stress in Nanomaterial Uptake by Cells: Focus on Targeted Anti-Cancer Therapy Cancers doi: 10.3390/cancers12071916 Authors: Samar Shurbaji Gulsen G. Anlar Essraa A. Hussein Ahmed Elzatahry Huseyin C. Yalcin Recently, nanomedicines have gained a great deal of attention in diverse biomedical applications, including anti-cancer therapy. Being different from normal tissue, the biophysical microenvironment of tumor cells...
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Cancers, Vol. 12, Pages 1915: Humanized Mice Are Precious Tools for Preclinical Evaluation of CAR T and CAR NK Cell Therapies Cancers doi: 10.3390/cancers12071915 Authors: Rana Mhaidly Els Verhoeyen Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for hematological malignancies. However, improvements in CAR T-cell therapies are urgently needed since CAR T cell application is associated with toxicities, exhaustion, immune suppression, lack of long-term...
Wed Jul 15, 2020 03:00
Cancers, Vol. 12, Pages 1914: Locoregional Therapy Approaches for Hepatocellular Carcinoma: Recent Advances and Management Strategies Cancers doi: 10.3390/cancers12071914 Authors: Mina S. Makary Umang Khandpur Jordan M. Cloyd Khalid Mumtaz Joshua D. Dowell Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and third leading cause of cancer-related mortality worldwide. While surgical resection and transplantation are the standard first-line treatments...
Wed Jul 15, 2020 03:00
Cancers, Vol. 12, Pages 1913: The LIM Protein Ajuba Augments Tumor Metastasis in Colon Cancer Cancers doi: 10.3390/cancers12071913 Authors: Noëlle Dommann Daniel Sánchez-Taltavull Linda Eggs Fabienne Birrer Tess Brodie Lilian Salm Felix Alexander Baier Michaela Medová Magali Humbert Mario P. Tschan Guido Beldi Daniel Candinas Deborah Stroka Colorectal cancer, along with its high potential for recurrence and metastasis, is a major health burden. Uncovering...
Wed Jul 15, 2020 03:00
Cancers, Vol. 12, Pages 1912: Role of ETS1 in the Transcriptional Network of Diffuse Large B Cell Lymphoma of the Activated B Cell-Like Type Cancers doi: 10.3390/cancers12071912 Authors: Valdemar Priebe Giulio Sartori Sara Napoli Elaine Yee Lin Chung Luciano Cascione Ivo Kwee Alberto Jesus Arribas Afua Adjeiwaa Mensah Andrea Rinaldi Maurilio Ponzoni Emanuele Zucca Davide Rossi Dimitar Efremov Georg Lenz Margot Thome Francesco Bertoni Diffuse...
Wed Jul 15, 2020 03:00
Cancers, Vol. 12, Pages 1911: Combined Systematic Review and Transcriptomic Analyses of Mammalian Aquaporin Classes 1 to 10 as Biomarkers and Prognostic Indicators in Diverse Cancers Cancers doi: 10.3390/cancers12071911 Authors: Pak Hin Chow Joanne Bowen Andrea J Yool Aquaporin (AQP) channels enable regulated transport of water and solutes essential for fluid homeostasis, but they are gaining attention as targets for anticancer therapies. Patterns of AQP expression and survival...
Wed Jul 15, 2020 03:00
Cancers, Vol. 12, Pages 1909: The Activity of KIF14, Mieap, and EZR in a New Type of the Invasive Component, Torpedo-Like Structures, Predetermines the Metastatic Potential of Breast Cancer Cancers doi: 10.3390/cancers12071909 Authors: Tatiana S. Gerashchenko Sofia Y. Zolotaryova Artem M. Kiselev Liubov A. Tashireva Nikita M. Novikov Nadezhda V. Krakhmal Nadezhda V. Cherdyntseva Marina V. Zavyalova Vladimir M. Perelmuter Evgeny V. Denisov Intratumor morphological...
Wed Jul 15, 2020 03:00
Cancers, Vol. 12, Pages 1910: Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates Cancers doi: 10.3390/cancers12071910 Authors: Ivana Samaržija Ana Dekanić Jonathan D. Humphries Mladen Paradžik Nikolina Stojanović Martin J. Humphries Andreja Ambriović-Ristov Integrins are heterodimeric cell surface receptors composed of α and β subunits that control adhesion, proliferation and gene expression. The integrin...
Wed Jul 15, 2020 03:00
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