Outcomes after Proton Therapy for Treatment of Pediatric High-Risk Neuroblastoma

Primary site irradiation for patients with high-risk neuroblastoma is necessary, but is associated with exposure of uninvolved kidneys, liver, and bowel. Proton therapy may spare normal tissues. We present the largest ever population of patients with neuroblastoma treated with proton therapy, demonstrating minimal toxicity and 97% local disease free survival. This treatment is safe and allows minimization of dose to normal tissues in young patients with neuroblastoma, who require intensive multimodality therapy.

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