21st Century FOX: Toward Gene Therapy for the Regulatory T Cell Deficiency Syndrome IPEX

IPEX is a fatal X-linked autoimmune disorder that results from mutations in the canonical regulatory T cell transcription factor FOXP3. In this issue of Cell Stem Cell, Masiuk et al. (2019) demonstrate an effective and potentially durable approach to eliminate the IPEX phenotype in murine models.

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