Engineering Biomimetic Materials for Skeletal Muscle Repair and Regeneration

Skeletal muscle tissue engineering approaches are reviewed, with a focus on the effects of biomaterials, soluble factors, mechanical factors that modulate skeletal muscle morphogenesis, and function. The therapeutic efficacy of engineered muscle in preclinical settings of muscle injury is then described.

Abstract

Although skeletal muscle is highly regenerative following injury or disease, endogenous self‐regeneration is severely impaired in conditions of volume traumatic muscle loss. Consequently, tissue engineering approaches are a promising means to regenerate skeletal muscle. Biological scaffolds serve as not only structural support for the promotion of cellular ingrowth but also impart potent modulatory signaling cues that may be beneficial for tissue regeneration. In this work, the progress of tissue engineering approaches for skeletal muscle engineering and regeneration is overviewed, with a focus on the techniques to create biomimetic engineered tissue using extracellular cues. These factors include mechanical and electrical stimulation, geometric patterning, and delivery of growth factors or other bioactive molecules. The progress of evaluating the therapeutic efficacy of these approaches in preclinical models of muscle injury is further discussed.

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