A Case of EBV‐Associated Blastic Lymphoplasmacytic Proliferation in an Esophageal Ulcer with a Self‐Limiting Course: Overlapping Lesion between EBV Mucocutaneous Ulcer and Polymorphic Lymphoplasmacytic Disorder

Abstract

B cell lymphoproliferative disorders (LPD) of varied malignant potential occur in association with immunodeficiency and include among others, follicular hyperplasia, infectious mononucleosis‐like hyperplasia, plasmacytic hyperplasia, polymorphic B‐lymphoproliferative disorders and the recently described clinicopathologic entity named as EBV‐positive mucocutaneous ulcer (EBV‐MCU). EBV‐MCU is a localized and usually self‐limited EBV‐associated LPD characterized by a circumscribed ulcer involving oropharyngeal mucosa, skin, or gastrointestinal tract reported most often in elderly patients with presumed age‐associated immunodeficiency. Histologically, EBV‐MCU is characterized by a polymorphous infiltrate, which frequently includes atypical large B cells with Hodgkin/Reed‐Sternberg (HRS) like cells admixed with abundant reactive T cells usually forming a rim around the base of the lesion.

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