Aiweixin, a Traditional Uyghur Medicinal Formula, Extends the Lifespan of Caenorhabditis elegans

Aiweixin (AWX) is a traditional Uyghur medicine prescription, which has been used to treat senile diseases for a long time. We investigate whether the AWX extends the lifespan of Caenorhabditis elegans. The AWX decoction was the conventional product for clinical use. The wild-type Caenorhabditis elegans (N2) and mutational worms, daf-16(mu86), glp-1(e2141), daf-2(e1370), and eat-2(ad465), were applied for the lifespan analysis. We found that the lifespan of the N2 adults' worm received 0.005 and 0.01 volume of AWX/total volume was extended significantly, compared to the control without treatment of AWX. The AWX at 0.01 volume of AWX/total volume significantly prolonged the life of both mutational worms, daf-16 (mu86) and eat-2(ad465), but did not increase the lifespan of the mutational worms, daf-2(e1370) and glp-1(e2141). These results indicated that the AWX significantly extended the lifespan of wild-type nematodes, and the life extension effect of AWX was related to the germline longevity pathway and IIS signaling pathway but independent of DAF-16/FOXO.

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