Immunosuppressive TNI -based reconditioning regimens after graft rejection or graft failure in pediatric patients treated with myeloablative allogeneic hematopoietic cell transplantation

This retrospective analysis aims to address the efficacy of total nodal irradiation- based reconditioning regimens on pediatric patients with graft failure or graft rejection after allogeneic haematopoietic cell transplantation. Results of 33 pediatric patients with malignant (n=25) and non-malignant diseases (n=8) were analysed. The TNI-based reconditioning regimen provides sustained engraftment combined with a favourable acute and late toxicity profile leading to long-term event-free and overall survival.

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