Virtual chromoendoscopy using optical enhancement improves the detection of Barrett’s esophagus–associated neoplasia

The Seattle protocol for endoscopic Barrett's esophagus surveillance samples a small proportion of the mucosal surface area – risking a potentially high miss rate of early neoplastic lesions. We assess if the new iScan Optical Enhancement system (OE, Pentax) improves the detection of early BE associated neoplasia compared with high definition white light endoscopy (HD-WLE) in both expert and trainee endoscopists to target sampling of suspicious areas. Such a system may both improve early neoplasia detection and reduce the need for random biopsies.

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