Modeling the axon as an active partner with the growth cone in axonal elongation

Forces generated by the growth cone are vital for the proper development of the axon and thus brain function. Whilst recent experiments show that forces are generated along the axon, it is unknown whether the axon plays a direct role in controlling growth cone advance. Here, we use analytic and finite element modeling of microtubule dynamics and the activity of the molecular motors myosin and dynein to investigate mechanical force balance along the length of the axon and its effects on axonal outgrowth.

https://ift.tt/2IB63XF