Passive permeability of planar lipid bilayers to organic anions

The membrane permeability P of organic ions was reported to be governed by the structure of the permeating molecule. Thus far it is unclear whether the ion structure alters membrane partition or translocation proper across the membrane. Here we obtained P values for 24 anionic compounds (18 concrete values, 6 upper limits) measuring the current that they carry through folded planar lipid bilayers. The P values range over more than 10 log units. Our measured permeability values correlate well (r=0.95; logRMSE 0.74) with the hexadecane/water partition coefficients of the respective chemicals predicted by the COSMO-RS theory.

https://ift.tt/2ICh1fs