Diffusion-Tensor Tractography of the Auditory Neural Pathway

Abstract

Purpose

The purpose of this study was to evaluate the structural integrity of the auditory neural pathway in patients with unilateral sensorineural hearing loss using quantitative diffusion-tensor tractography.

Methods

Diffusion-tensor tractography imaging was performed using a 3T magnetic resonance imaging system to evaluate structural alterations in the auditory neural pathway of patients with unilateral sensorineural hearing loss. The two diffusion-tensor tractography parameters, fractional anisotropy and the apparent diffusion coefficient were compared between the ipsilateral side and the contralateral side in patients and controls. Additionally, correlations between the parameter values and the hearing loss level in patients were evaluated.

Results

A total of 24 sensorineural hearing loss patients (14 males; age range, 17–65 years; average age, 45.3 years) and 24 age and sex-matched control subjects were enrolled. Fractional anisotropy values on the ipsilateral and contralateral sides were significantly lower in patients than in the control group (p = 0.004 and 0.001, respectively). The differences in the apparent diffusion coefficient values for the ipsilateral and contralateral sides between the two groups were not significant (p = 0.279 and 0.248, respectively). There was an inverse relationship between fractional anisotropy and the severity of hearing impairment on the ipsilateral and contralateral sides (r = −0.519, p = 0.005 and r = −0.454, p = 0.015, respectively). No significant correlation was found between the apparent diffusion coefficient and hearing loss level on the ipsilateral and contralateral sides (r = 0.172, p = 0.380 and r = 0.131, p = 0.508, respectively).

Conclusion

Quantitative diffusion-tensor tractography can be used to detect microstructural alterations in the auditory neural pathway in sensorineural hearing loss patients with normal results in standard imaging studies.

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