Comparison of the drug-drug interaction potential of daptomycin in combination with rifampin in healthy adult volunteers [Pharmacology]

We evaluated the effect of rifampin co-administration and MDR1 single nucleotide polymorphisms on the disposition of daptomycin in twelve healthy adults. There were no significant changes from baseline in clearance (0.53 vs 0.55 L/hr, P = 1.00), volume of distribution (7.0 vs 7.2 L, P = 0.62), or half-life (9.7 vs 9.6 hrs, P = 0.89) of daptomycin after exposure to rifampin. The tested MDR1 polymorphisms were not associated with significant differences in daptomycin disposition.

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