Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis

Coll et al. describe efficient differentiation of human pluripotent stem cells into hepatic stellate cell-like cells (iPSC-HSCs). iPSC-HSCs share phenotypic and functional features with primary HSCs and are useful for studying HSC development and for the generation of 3D in vitro liver systems for toxicity assessment and fibrosis modeling.

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