Whole Exome Sequencing Identifies Unique Mutations and Copy Number Losses in Calcifying Fibrous Tumor of the Pleura: Report of Three Cases and Review of the Literature

Calcifying fibrous tumor of the pleura (CFTP) is a rare mesenchymal tumor of unknown pathogenesis. The diagnosis often requires exclusion of other common entities. Our aim was to determine if genomic changes were associated with CFTP that could contribute to mechanisms underlying tumorigenesis. Three cases of CFTP with their corresponding uninvolved control lung tissue were identified. Two patients were male, and one was female (age range: 21–32years). Tumors were multifocal in two cases and solitary in one.

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