Decreased expression of microRNA-26b in locally advanced and inflammatory breast cancer

Advanced-stage breast cancer patients comprise a smaller proportion of breast cancer patients than do early-stage patients and are more likely to experience a poor outcome. Understanding the underlying molecular mechanisms and identifying new biomarkers for treatment in this subgroup of patients is paramount. With the aim of identifying microRNAs that are regulated in advanced-stage breast cancer, we found lower expression of miR-26b, a member of the miR-26 family, in inflammatory breast cancer and noninflammatory locally advanced breast cancer tissue than in normal breast tissue, by quantitative real-time PCR and in situ hybridization.

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