Implications of Pathological Complete Response (pCR) Beyond Mediastinal Nodal Clearance with High-dose Neoadjuvant Chemoradiotherapy (CRT) in Locally Advanced, Non-Small Cell Lung Cancer (LA-NSCLC)

Mediastinal response guides decision for surgery in LA-NSCLC patients treated with neoadjuvant therapy, where mediastinal nodal clearance (MNC) is strongly associated with improved survival. The added benefit of a pathologic complete response (pCR), with no viable tumor in both the mediastinum and primary site is not known, which is the objective of this large, single-institutional analysis using a high-dose neoadjuvant chemoradiation (CRT) approach.

http://ift.tt/2nXsVri