Abstract
In this work, a novel ruthenium complex loaded monolayer layered double hydroxide (LDH) (denoted as Ru(C-bpy)2/mLDH) as supramolecular nanosensor is synthesized, which is greatly exclusive to the hypoxic tumor microenvironment. The Ru(C-bpy)2/mLDH ultrathin sheet displays not only enhanced luminescence lifetime compared to the parent Ru(C-bpy)2 alone, but also improved oxygen responsibility under an excitation of 488 or 800 nm. Moreover, the Ru(C-bpy)2/mLDH is possessed of two-photon fluorescence imaging ability under the 800 nm irradiation. In addition, the Ru(C-bpy)2/mLDH can generate singlet oxygen with a high yield (φ∆) of 0.28 under the 520 nm irradiation, while the φ∆ of Ru(C-bpy)2 is 0.19. Therefore, the Ru(C-bpy)2/mLDH can be applied as a supramolecular theranostic agent with light-switchable cancer imaging and photodynamic therapy properties.
Ruthenium complex is loaded to the monolayer of layered double hydroxides to gain supramolecular nanosheet (Ru(C-bpy)2/mLDH) as a theranostic agent, which exhibits oxygen sensitivity for photoluminescent imaging of hypoxia condition in solid tumor and the capacity to generate singlet oxygen for photodynamic therapy. The therapeutic and diagnostic functions can be switched by alternating the excitation wavelength.
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