Anidulafungin pharmacokinetics in ascites and pleural effusion of critically ill patients [PublishAheadOfPrint]

Anidulafungin concentrations were quantified with high pressure liquid chromatography (HPLC) and UV detection in ascites and in pleural effusion of ten adult critically ill patients. Samples were collected from ascites and from pleural drains or during paracentesis and thoracentesis, respectively. Anidulafungin levels in ascites (0.12-0.99 μg/ml) and in pleural effusion (0.32-2.02 μg/ml) were below the simultaneous plasma levels (1.04-7.70 and 2.48-13.36 μg/ml, respectively) and below the MIC values of several pathogenic Candida strains.

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