Opportunities and Challenges in Genomic Sequencing for Precision Cancer Care

Cancer is defined by diverse somatic and germline alterations that promote aberrant cell growth. Tumor genomic profiling to guide therapy is now part of standard management in several solid tumor types. The authors discuss how recent technical advances in next-generation sequencing technology, coupled with decreasing costs, present a transformative opportunity to improve patient outcomes through implementation of routine, prospective tumor and germline genomic profiling.

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