The effect of replicative aging on antifungal resistance in Candida glabrata was investigated. Our studies demonstrate significantly increased transcription of ABC transporters as well as efflux pump activity in old compared to young C. glabrata cells of a fluconazole sensitive and resistant strain. In addition, higher tolerance to killing by micafungin and amphotericin B was noted and is associated with higher transcription of glucan synthase gene FKS1 and lower ergosterol content in older cells.
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