Risk Factors for Malignant Transformation of Low Grade Glioma

The incidence, risk factors, and outcomes of LGG patients who undergo malignant transformation in the era of temozolomide are not well known. This study evaluates these factors from a large group of WHO Grade II glioma patients treated at our tertiary care institution. We found that older age, male sex, multiple tumor locations, chemotherapy alone, and extent of resection were significant predictors of malignant transformation.

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