Inhibitors of HIF-1α and CXCR4 Mitigate the Development of Radiation Necrosis in Mouse Brain

The efficacy of a HIF-1α inhibitor, topotecan, and a CXCR4 antagonist, AMD3100, on the development of radiation necrosis was investigated in an intracranial mouse model. Mice were irradiated with the Leksell GammaKnife® PerfexionTM, and the development and progression of radiation necrosis were monitored longitudinally in vivo using magnetic resonance imaging, supported with correlative histology. Both topotecan and AMD3100 can, independently, mitigate the development of RN in mouse brain by reducing inflammation.

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