Associations of Genetic Variations in the Seed Regions of MicroRNAs with Acute Adverse Events and Survival in Patients with Rectal Cancer Receiving Postoperative Chemoradiotherapy

MicroRNAs play a key role in posttranscriptional regulation of mRNA and multiple cellular biological processes. We analyzed 18 SNPs in microRNA seed regions and identified two SNPs associated with acute adverse events and survival time in patients with rectal cancer receiving CAP-based chemoradiotherapy. These SNPs might serve as independent biomarkers for predicting acute adverse events and prognosis in patients with rectal cancer. Independent replication studies are required to confirm these results.

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