Punctaporonins N–S, New Caryophyllene Sesquiterpenoids from Cytospora sp.

Six new caryophyllene sesquiterpenoids, punctaporonins N–S (1–6), and three known ones, 6-hydroxypunctaporonins B (7), A (8), and E (9), have been isolated from solid cultures of Cytospora sp. The structures of 1–6 were elucidated primarily by NMR spectroscopy. The absolute configuration of 1 was assigned by X-ray crystallographic analysis of its -MTPA ester. Compounds 2, 5, and 6 showed modest cytotoxicity against HeLa cells.

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