The ability to survive desiccation is a rare, but widespread trait found in at least some organisms within every kingdom of life. An enigmatic group of proteins, intrinsically disordered proteins (IDPs), have emerged as hallmarks of desiccation tolerance. As discussed by Boothby and Pielak in article number 1700119, how IDPs mediate survival during drying is unknown, but uncovering their mechanism(s) of protection is essential for understanding this enigmatic phenomenon.
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