Insulin-like growth factor II messenger RNA-binding protein-3 is an independent prognostic factor in uterine leiomyosarcoma

Abstract

Aims

We aimed to identify the prognostic factors of uterine leiomyosarcoma (ULMS).

Methods and results

We reviewed 6160 cases of surgically resected ULMSs and investigated conventional clinicopathological factors, together with the expressions of insulin-like growth factor II messenger RNA-binding protein-3 (IMP3), hormone receptors and cell cycle regulatory markers by immunohistochemistry. In addition, mediator complex subunit 12 (MED12) mutation analysis was also performed. Univariate analyses revealed that advanced stage (p<0.0001), older age (p=0.0244) and IMP3 expression (p=0.0011) were significant predictors of a poor outcome. Multivariate analysis revealed advanced stage (p<0.0001) and IMP3 (p=0.0373) as independent predictors of a poor prognosis. Expressions of cell cycle markers and hormone receptors, and MED12 mutations (12% in ULMSs) were not identified as prognostic markers in this study.

Conclusions

IMP3 expression in ULMS could be a marker of a poor prognosis.

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