A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages

Tchieu et al. develop a chemically defined culture platform that allows parallel derivation of human PSCs into all major ectodermal lineages. The utility of this platform is shown through genetic dissection of the roles of TFAP transcription factors in ectoderm and a chemical screen that identified compounds promoting cranial placode differentiation.

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