Intraoperative subdural low-noise EEG recording of the high frequency oscillation in the somatosensory evoked potential

Pathological high frequency oscillations (pHFOs, 80-500 Hz) recorded in the pre and intra-operative ECoG of epilepsy patients have been proposed as a biomarker for the identification of the epileptogenic zone (Jacobs et al., 2012). Particularly for epilepsy surgery, it has been demonstrated that residual fast ripples (FR, > 250 Hz) are a reliable predictor of seizure outcome (Fedele et al., 2017; van 't Klooster et al., 2015; Wu et al., 2010). While faster oscillations have higher clinical relevance, they suffer from a poor signal-to-noise ratio (SNR).

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