Identical TP53 mutations provide evidence that late recurring tubo-ovarian high grade serous carcinomas do not represent new peritoneal primaries

Abstract

Tubo-ovarian high-grade serous carcinoma (HGSC) is the most common female adnexal malignancy and by far the most lethal. There is now compelling evidence that most of these neoplasms arise from the distal fallopian tube from a precursor referred to as serous tubal intraepithelial carcinoma (STIC) (1-5). Most cases present at advanced stage (FIGO stages III-IV) and the overall prognosis is poor (6). While most cases respond well initially to chemotherapy, early recurrence (within a few years) is common and most patients will eventually succumb to their disease (6)

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