In vitro isolation and characterization of oxazolidinone resistant Mycobacterium tuberculosis [PublishAheadOfPrint]

Oxazolidinones are promising candidates for the treatment of Mycobacterium tuberculosis infections. We isolated linezolid resistant strains from H37Rv (Euro-American) and HN878 (East-Asian) strains; resistance frequency was similar in both strains. Mutations were identified in ribosomal protein L3 (RplC) and the 23S rRNA (rrl). All mutant strains were cross resistant to sutezolid; a subset were cross-resistant to chloramphenicol. Mutations in rrl led to growth impairment and decreased fitness that could limit spread in clinical settings.

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