Phase I-II Study of Dual-Energy Computed Tomography (DECT) for Assessment of Pulmonary Function in Radiotherapy Planning

This prospective study evaluated the role of DECT-iodine maps for the assessment of lung function in radiotherapy planning. Using a 2-material decomposition method, iodine concentration of whole lung volume was used as an indicator of regional perfusion. DECT-iodine map provided accurate lung function information. Significant differences in mean and low dose to whole vs. functional lung volumes were found with integration of DECT-iodine maps in early and advanced stage lung cancer radiotherapy planning.

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