Encapsulation of cholecalciferol and ergocalciferol in oil-in-water emulsions by different homogenization techniques
Nauman Khalid, Isao Kobayashi, Marcos A. Neves, Kunihiko Uemura, Mitsutoshi Nakajima, and Hiroshi Nabetani
Ergocalciferol and cholecalciferol are bioactive compounds whose deficiency in human system results in rickets, osteoporosis and osteomalacia. Different homogenization methods were used to formulate stable food-grade oil-in-water (O/W) emulsions encapsulating a mixture of ergocalciferol and cholecalciferol. The O/W emulsions formulated under appropriate homogenization conditions remained stable in terms of variation of their volume mean diameter over 30 days. Release profile of ergocalciferol and cholecalciferol encapsulated in the O/W emulsions was little affected by the homogenization methods used.
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